Literature summary extracted from

Burrows, J.F.; Kelvin, A.A.; McFarlane, C.; Burden, R.E.; McGrattan, M.J.; De la Vega, M.; Govender, U.; Quinn, D.J.; Dib, K.; Gadina, M.; Scott, C.J.; Johnston, J.A.
USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity (2009), J. Biol. Chem., 284, 9587-9595.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.99.B1	USP17	USP17 deubiquitinates RCE1 and negatively regulates the activity of RCE1. Constitutive expression of USP17 blocks cell growth and decreases Ras activation, knockdown of USP17 expression results in a marked elevation in the level of GTP-bound Ras. USP17 and RCE1 co-localize at the endoplasmic reticulum	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.99.B1	endoplasmic reticulum membrane	RCE1 colocalizes with USP17 in the endoplasmic reticulum	Homo sapiens	5789	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.99.B1	Homo sapiens	-	-	-

Posttranslational Modification

EC Number	Posttranslational Modification	Comment	Organism
3.4.99.B1	additional information	RCE1 is regulated by ubiquination, deubiquitinating enzyme USP17 negatively regulates the activity of RCE1, overview	Homo sapiens

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.99.B1	HeLa cell	-	Homo sapiens	-

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.99.B1	Ras-converting enzyme 1	-	Homo sapiens
3.4.99.B1	RCE1	-	Homo sapiens

General Information

EC Number	General Information	Comment	Organism
3.4.99.B1	metabolism	the deubiquitinating enzyme USP17 negatively regulates the activity of RCE1	Homo sapiens
3.4.99.B1	physiological function	RCE1 is involved in Ras trafficking to the plasma membrane and the Ras/MEK/ERK pathway. USP17 regulation of growth is RCE1-dependent, overview	Homo sapiens

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Release 2023.1 (January 2023)